According to previous reports, PD-L1 expression has been reported to range from approximately 45% to 65% of immune cells within the tumor microenvironment and from 10% to 70% of tumor specimens [30,31]; in addition, PD-L1 expression by both intra-tumoral inflammatory or neoplastic cells has been related to tumor aggressiveness and worse survival [32,33]. The gene discussed is CD274; the disease is neoplasm.