We performed research using PubMed/Medline, Cochrane Library, and Scopus with the keywords “biliary tract cancer” OR “cholangiocarcinoma” OR “intrahepatic cholangiocarcinoma” OR “extrahepatic cholangiocarcinoma” OR “gallbladder cancer” AND “immunotherapy” OR “immune checkpoint inhibitors” AND “PD-L1” OR “tumor mutational burden” OR “TMB” OR “MSI” OR “DDR” OR “DNA damage repair” OR “tumor microenvironment.” We selected pivotal registration studies. Here, CD274 is linked to neoplasm.