In this review, 7 potential targets for fluorescence-guided surgery of STS (TEM1, VEGFR-1, EGFR, VEGFR-2, IGF-1R, PDGFRα, and CD40) were selected based on antibodies that are clinically available and mostly used in the antibody-based therapy of STS. The gene discussed is IGF1R; the disease is telomere syndrome.