In this subtype, FOXM1, TOP2A, CCNB1, CCNB2, and CDC25A participate in DNA repair and are activated during disease relapse [9,10,11,20] or play a role in the prognosis of other cancers [21,22], thereby supporting the poor prognostic characteristics of the DP.BCG+ subtype. The gene discussed is CDC25A; the disease is cancer.