IL4 and neoplasm: The EMT-initiated tumor cells produce EMT-inducible molecules to further facilitate EMT in an autocrine manner: for example, chemokine ligand 2 (CCL2) through the Hedgehog signaling pathway [26,27], IL4 through the E2F11/SP3/STAT6 pathway [28,29], and IL35, a member of the IL12 family, through the GP130-STAT1 pathway [30], suggesting a feedback loop for EMT amplification.