EGF and neoplasm: Epithelial tumor cells adhere to each other via tight junctions, but sometimes transform into mesenchymal types with low adhesive but high invasive properties in response to extrinsic stimuli, such as hypoxia and inflammation mediated by numerous factors, including WNT, NOTCH, transforming growth factor beta (TGFβ), epidermal growth factor (EGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and hypoxia inducible factor (HIF) within the tumor microenvironment [1,2].