If early diagnosis and treatment of CRC can significantly improve the cure rate, traditional biomarkers (Carcino Embryonic Antigen (CEA), Carbohydrate Antigen 19-9 (CA19-9), Fecal Occult Blood Test (FOBT)) as well as colon/sigmoidoscopy do not fully satisfy clinical needs in CRC screening due to their lack in sensitivity and specificity [2]. This evidence concerns the gene CEACAM5 and colorectal carcinoma.