CXCL12 and Familial prostate cancer: Besides, SDF1 represents an important element in the regulation of hematopoietic stem cell (HSC) homing to the bone marrow, with previous reports suggesting that HSC homing has many similarities with bone metastasization mechanisms in prostate cancer, due to the analogous expression of several chemokines—including SDF1, CXCR7, and CXCR4 [22].