SREBF1 and cancer: Although SREBP-1 suppressing effect of adiponectin has not been confirmed in cancer cells yet, this effect is predictable, based on the fact that adiponectin prevents phosphorylation of mTORC1, a key upstream regulator of SREBP-1 and lipid synthesis, via either activation of AMPK or blockage of PI3K/Akt signaling [99].