Moreover, adipose tissues secret a number of other cytokines, including interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and monocyte-chemoattractant protein-1 (MCP-1), which may also contribute to obesity-promoted cancer initiation and progression [13]. The gene discussed is CCL2; the disease is obesity due to melanocortin 4 receptor deficiency.