TNF and rheumatoid arthritis: In a recent systematic review and meta-analysis of six studies in 123,023 patients, an increased risk of NMSC (RR: 1.3; 95% CI: 1.2–1.4; p = 0.056), especially SCC (RR: 1.3; 95% CI: 1.1–1.5; p = 0.854) but not BCC (RR: 1.1; 95% CI: 1.0–1.3; p = 0.555), was observed in patients with RA treated with TNF inhibitors compared with patients not receiving TNF inhibitors [172].