To provide comprehensive evidence that LSD1 and UTX inhibition by MC3324 modulates the ERα signaling pathway and its interactome via functional activity of miR-181a-5p, we compared data in ERα-positive (MCF-7) and ERα-negative (MDA-MB-231) BC models, as shown in Figure 3B,C. The gene discussed is ESR1; the disease is breast cancer.