CD8A and neoplasm: In contrast, anti-tumor factors include high NK cells; high type I M1 macrophages; high type I CD4+ Th1 cells; low Tregs; high tumor infiltrating CD8+ T cells (memory, cytotoxic); high type I cellular immune response (e.g., IFN-g, IL-2, granzyme B); more and functional TILs (hot tumor); and high antigenicity and immunogenicity of the tumor cells (Figure 2) [31,32,33,36,37,38,39,40,41,42,43,44].