METTL3 and Autoimmunity: Using a similar Mettl3 conditional KO mouse model, the authors analyzed the Tregs subset (Mettl3-/- and WT) of CD4+ T cells and found that Mettl3 -/- Tregs mice developed severe autoimmune disorders compared to WT, suggesting loss of m6A modification can lead to loss of Treg immune suppressive functions [127].