Expression of the Nlrp3 gene increased in the spinal cord during the progression of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and deletion of the Nlrp3, Casp1, Pycard, or Il1b genes in mice led to resistance to EAE [34,35,36]. The gene discussed is NLRP3; the disease is myeloid sarcoma.