RAF1 and hepatocellular carcinoma: Among other evidence supporting this protective effect of the indoleamine on the development of HCC is the fact that melatonin can inhibit the proliferation, migration, and invasion capacities of Huh7 and HepG2 hepatoma cell lines by inducing the expression of the miRNA let7i-3p, which reduces Raf1 expression, eventually reducing the activation of mitogen-activated protein kinase signaling downstream from RAF1 [305].