PSEN1 and familial Alzheimer disease: These are transgenic mice over-expressing mutant human amyloid precursor protein (APP695) with the Swedish (K670N, M671L), Florida (I716V), and London (V717I) mutations along with human presenilin 1 (PSEN1) harboring two (M146L and L286V) mutations, all known to accelerated accumulation of Aβ and development of early onset familial AD (FAD).