h-ANG, also known as ribonuclease 5 (RNase 5) because it is included in the secretory pancreatic-type RNase super-family [12], is a 123 residue (14.1 kDa) protein [13] present in plasma [14], cerebrospinal and amniotic fluid [15] and in tumor microenvironments. The gene discussed is ANG; the disease is neoplasm.