Taken together, since Chga-knockout mice showed a reduction in the preclinical setting of colitis [23], and some CgDPs protected against colitis [4,10,11,20,24,25], we hypothesized that PST could be one of the proinflammatory CgDPs that enhance the colonic inflammatory process through an alteration of the functional capacities of AAM and subsequently IECs. Here, CHGA is linked to colitis.