Using in vitro and in vivo knockdown approaches, the authors were able to demonstrate that FGFR1/PlCγ/HIF1α signalling pathway confers radioresistance to GB cells (e.g., U87, LN18) and derived tumor mouse xenografts via controlling radiation-induced centrosome overduplication and radiation-induced mitotic cell death. This evidence concerns the gene HIF1A and neoplasm.