SSTR5 and growth hormone-producing pituitary gland neoplasm: Actually, SST2,SST3, and SST5 trigger inhibition of GH synthesis in pituitary somatotropinoma [39,40,41] Moreover, it has been shown in different cell types, that somatostatin induces also inhibition of tumor necrosis factor-α and interleukins secretion also involved in the regulation of cell proliferation [42,43].