Experiments on the APS prone mouse model ((NZW × BXSB)F1 mice) showed that BAFF blockade is able to reduce the occurrence of myocardial infarction [49]; nevertheless, no significant effect was obtained on aPL titers in a 12-month follow-up study carried out on patients treated with rituximab [50]. Here, TNFSF13B is linked to autoimmune polyendocrinopathy.