LGDs and platelets can release mitochondria and mitochondrial DNA (mtDNA), which are strongly involved in inducing pro-inflammatory cytokines, including type I IFN, IFNγ, IL-6, IL-8, and TNFα, all actors in the context of the autoimmune pathogenesis of APS [56]. The gene discussed is TNF; the disease is autoimmune polyendocrinopathy.