Finally, we performed the receiver operating characteristic (ROC) curve analysis and Kaplan-Meier analysis to determine potential application value of KPNA4 in HCC; and found that KPNA4 may serve as a biomarker to diagnose HCC (area under the ROC curve [AUC] = 0.726, 95% CI: 0.569-0.882, P = 0.029; Figure 9E), and to predict patient prognosis (Figure 9F, P = 0.005). Here, KPNA4 is linked to hepatocellular carcinoma.