GRB2 associated binding protein 2/3 (Gab2/3) double knockout mice could develop spontaneous colitis with rectal prolapse and diarrhea, mainly involving macrophages and CD8+ T cells, which was due to the role of Gab2/3 in suppressing the inactivation of immune cells in the process of inflammation [58]. This evidence concerns the gene CD8A and Rectal prolapse.