Johnson et al. reported significantly higher methylation rates of bone morphogenic protein 3 (BMP3) or N-Myc downstream-regulated gene 4 (NDRG4) in IBD lesions than matched controls, which revealed that specific DNA markers that were present in advanced IBD neoplasia could be detected in the tissues and feces when small adenomas occur in IBD patients [9]. This evidence concerns the gene BMP3 and inflammatory bowel disease.