NOTCH1 and triple-A syndrome: In this study, AngII promoted NLRP3 activation both in AAA mouse model and cultured macrophages; both IMD and DAPT reversed NLRP3 expression, so IMD may inhibit the activation of NLRP3 in macrophages by blocking the Notch1 signaling pathway, thereby preventing the initiation of the early inflammatory response of AAA.