NOS2 and triple-A syndrome: In mice AAA tissue, the M1 macrophage polarization marker iNOS was increased in Ang II group compared with control, IMD and DAPT could decrease the iNOS expression; M2 macrophage polarization marker Arg1 was activated in Ang II group, which increased more in IMD and DAPT group (Supplementary Figure 2A, 2B).