For instance, Majbour et al. reported that cerebrospinal fluid alpha-synuclein species correlated with the progression of motor impairment [12], Chung et al. constructed a model to predict later development of gait freezing in PD [13], and Hideyuki et al. reported that high C-reactive protein (CRP) levels were associated with shorter survival time and suggested that they may predict survival prognosis in patients with PD [14]. This evidence concerns the gene CRP and Parkinson disease.