Attesting to the validity of our research, the current findings overlap partially with those of Faner et al. [13], who also identified MS4A1, POU2AF1, FCRL5, COL1A2 as potential hub genes of emphysema and indicated also the potential involvement of BCR signaling pathway and ECM organization in its development. The gene discussed is COL1A2; the disease is pulmonary emphysema.