In our previous WGCNA study using GSE69818 dataset, IFT88, Bik, MMP10, and CCDC103 were identified as hub genes and were consistently expressed in patients with emphysema, the emphysema related genes were mainly enriched for apoptotic mitochondrial changes, proteolysis, and functions of cilium assembly and movement [12]. The gene discussed is BIK; the disease is pulmonary emphysema.