PBX2 genes are found to be abnormally expressed in different cancer types, including esophageal squamous cell carcinoma (ESCC), gastric carcinoma (GC) [25], gingival squamous cell carcinoma [27], along with non-small cell lung carcinoma (NSCLC) [28]. This evidence concerns the gene PBX2 and esophageal squamous cell carcinoma.