FCHSD2 and diabetes mellitus: To gain insight into the relevance of our findings in the context of human islet physiology and diabetes risk, we analyzed the expression of FCHSD2 in a cohort of 103 subjects who provided pancreatic samples after partial pancreatectomy and laser capture microdissection analysis (IMIDIA consortium; 47 non-diabetic, 56 T2D) (Solimena et al., 2018; Marchetti et al., 2018).