FCHSD2 and type 2 diabetes mellitus: We found that the T2D risk variants at the STARD10 locus reside in an islet enhancer hub that contains the genes ARAP1, STARD10, ATG16L2, and FCHSD2. Of note, the expression of ARAP1 in human islets is chiefly driven by two promoters that reside outside the enhancer hub (Figures 5A and S4C) and is thus not likely to be co-regulated with STARD10 and other hub genes, in line with evidence from eQTL studies (this report and Carrat et al., 2017).