INS and Hyperglycemia: Multiple studies of automated insulin delivery systems continue to dictate treatment of hypoglycemia with 15–20 g of CHO per protocol17–20 despite increasing recognition that this may lead to hyperglycemia from clinical experience.21,22 Notably, the pivotal study protocol that led to FDA approval of the Control-IQ system recommended CHO treatment for hypoglycemia but did not specify a CHO treatment amount.6