GYPC and infection: Although all the mice, even those inoculated with m8-N, m8-GPC, m8-N+GPC in advance, developed clinical symptoms after infection with 1 × 103 TCID50 or 1 × 105 TCID50 of SFTSV, the weight loss in the mice inoculated with m8-based SFTSV vaccines, especially those inoculated with m8-GPC or m8-N+GPC, was milder in comparison to mice inoculated with m8-EGFP (Fig 5C and 5D).