CXCL10 and infection: In mice infected with EEEV, IP-10 and other inflammatory cytokine/chemokine levels were only mildly elevated in the blood at 24 hours post-infection with wild-type virus [30], which was attributed to the binding of EEEV to heparan sulfate (41) and microRNA-mediated restriction or virus replication [31], both of which led to restricted infection of myeloid cells.