Since both enrichment and co-segregation of NRAP variants in DCM are unknown, our aims were to 1) evaluate whether patients who underwent genetic testing due to DCM have a higher frequency of NRAP variants compared to controls, 2) to study co-segregation of the NRAP variants, and 3) to define genotype-to-phenotype associations in NRAP-associated cardiomyopathy. Here, NRAP is linked to familial dilated cardiomyopathy.