Dermatophagoides pteronyssinus, a house dust mite allergen, is an important etiology for the development of atopic dermatitis and induces assembly of the NLRP3 inflammasome complex resulting in caspase-1 activation and IL-1β and IL-18 release from keratinocytes (Dai et al. 2011). This evidence concerns the gene CASP1 and atopic eczema.