We can also mention the case of the C–O–C type biflavone ochnaflavone which inhibits MMP-9 secretion in human aortic smooth muscle cells through the transcription factors NFκB and AP-1 [71] or a derivative of agathisflavone which suppresses MMP-2 expression and reduces metastasis of melanoma cells [72]. This evidence concerns the gene MMP9 and melanoma.