Similarly, amentoflavone was found to inhibit metastasis down-regulation of MMP-2 and -9 [68] and to block glioblastoma and osteosarcoma tumor progression through via suppression of the ERK/NFκB signaling pathway, with a down-regulation of MMP-2 and -9 [69, 70]. Here, MMP2 is linked to glioblastoma.