KEGG pathway analysis revealed that several important human pathways are related to viral integration, including gap junction, tight junction, axon guidance, long-term depression, glutamatergic synapse, arrhythmogenic right ventricular cardiomyopathy, PI3K–Akt signaling, thyroid hormone signaling and EGFR tyrosine kinase inhibitor resistance (Fig. 1c). Here, AKT1 is linked to Arrhythmogenic right ventricular dysplasia.