CD4 and COVID-19: Our analyses were limited to the demographic and laboratory data available in NYS’s HIV surveillance registry and COVID-19 database, precluding a more in-depth understanding of the role played by comorbidities and underlying medical conditions, COVID-19 risk behaviors, and social determinants of health, which necessitates more comprehensive data sources, such as medical record reviews; however, the gradient in severity observed by CD4-defined HIV stage suggests a direct role for HIV disease.