Molecular alterations detected in CEBPα, TP53, and GATA2 have already been identified as high‐risk germline alleles with MN predisposition [27, 28, 29, 30, 31, 32],meanwhile, ASXL1 variant p.Gly704Arg has only been found in patients diagnosed from sporadic MN and missense MPL variant p.Phe105Leu has been previously described in a case of chronic myelomonocytic leukemia and in a case of Sézary syndrome [33, 34]. This evidence concerns the gene TP53 and chronic myelomonocytic leukemia.