Based on our TCGA analysis, JUP appears to reduce WNT target gene expression either in the overall PCa cohort (AXIN2, LEF1, NKD1) or specifically in ERG‐negative patients (MYC) while ERG fusion per se apparently induces WNT signaling to some extent (AXIN2, LEF1, but not NKD1 or MYC). Here, LEF1 is linked to posterior cortical atrophy.