In addition to the classical immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome due to FOXP3 mutation, the best characterized are CD25, CTLA4, and LRBA deficiencies, that is the absence of molecules as highly relevant for tTreg development and function, as mentioned earlier in this review [108–110]. Here, IL2RA is linked to Abnormal intestine morphology.