In addition to the classical immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome due to FOXP3 mutation, the best characterized are CD25, CTLA4, and LRBA deficiencies, that is the absence of molecules as highly relevant for tTreg development and function, as mentioned earlier in this review [108–110]. This evidence concerns the gene CTLA4 and Abnormal intestine morphology.