ADSL and infection: It is worth to note that the epidermis can also recognize the damage through hemidesmosomes associated with a STAT-like protein, whose disruption led to the detachment of STA-2 molecules from hemidesmosomes and initiation of the AMPs induction (Zhang et al. 2015), indicating that diverse strategies might be used as a response to epidermal damage that triggers the active innate immunity to protect from infection.