LDHA and central nervous system cancer: Upon visualizing the alternative methylation landscapes between the glycolysis-low cluster (IDH-mutant enriched) and the glycolysis-high cluster (IDH-wt enriched), there was a distinct difference in the global co-methylation landscape of glioma (Figure 1F), suggesting differential accumulation of 2HG.10,11 This observed association with glycolysis was in line with previous work,11,12,50 and encouraged us to examine whether this may reflect an individual epigenetic association in LDHA, a gene isoform that is critical for the Warburg Effect and the sustained activation of glycolysis.20,21