The IDH mutation in LGG has long been known as the hallmark bridge between the genetics and epigenetics of glioma.11 While this study allowed us to dive slightly deeper into the pathways associated with these epigenetic changes, it is important to note that glycolysis and immunosuppressive signaling likely mark merely two of the dozens of pathways affected by the IDH-mutant induced methylation.50 There are also several limitations to our study. Here, IDH2 is linked to central nervous system cancer.