Previous work has highlighted a link between glycolysis and immunosuppression in melanoma29 as well as the importance of epigenetic regulation of immune checkpoint expression in various tumor types.34,35,51,52 To explore whether these features were relevant in LGG, we first examined the expression of 9 immune checkpoint genes between the glycolysis-high cluster (IDH-wt enriched) and the glycolysis-low cluster (IDH-mutant enriched). This evidence concerns the gene IDH1 and neoplasm.