These results are in line with the unfavorable clinical features of glycolytic tumors across several tissue types,53 and the substantial evidence that pair wild-type IDH LGG patients with poor survival.2 Furthermore, while previous work has revealed an association between glycolysis and PD-L1 expression in several cancer types,54 PD-L2 has not been explored in the context of glycolysis, nor in the context of human LGG. Here, CD274 is linked to cancer.