Finally, CIN tumors are described as having structural chromosomal aneuploidy without hypermutation, frequent TP53 mutations, whole‐genome doubling, and amplification of cell‐cycle genes and genes from the receptor tyrosine kinase (RTK)‐RAS signaling pathway.26, 28, 38, 39. Here, TP53 is linked to cervical squamous intraepithelial neoplasia.