The circulating glucose in the post-absorptive state is captured by insulin-independent organs: brain (50%) and splanchnic organs (25%), with only the remainder (25%) being used in insulin-dependent tissues, especially the muscles skeletal, and, second, adipose tissue.30,31 However, any imbalance in this peripheral glucose uptake can lead to glucose intolerance or even diabetes mellitus. This evidence concerns the gene INS and Glucose intolerance.