sign.: serum cystatin C (OR 4.828 [95% CI 1.711‐13.620], P = .003), coronary artery disease (3.566 [1.470‐8.648], P = .005), insulin use (2.605 [1.258‐5.394], P = .01), difference between supine and sitting transcutaneous oxygen pressure (1.076 [1.032‐1.122], P = .001), hypertension (1.021 [1.003‐1.039], P = .023);. The gene discussed is INS; the disease is Hypertension.