APOE and Alzheimer disease: However, the modifying effect of APOE ɛ4 status on the association between AD‐PRS and dementia varies; clinical samples report a similar effect of AD‐PRS on AD in APOE ɛ4 carriers and non‐carriers,3, 5, 7 while the population‐based Rotterdam Study reported a higher effect of an AD‐PRS on AD and dementia among APOE ɛ4 carriers compared to non‐carriers.10