Among those aged 70 to 94 years, the 39‐SNPs AD‐PRS was associated with incident dementia in APOE ɛ4 non‐carriers (HR 1.16; 95% CI 1.01–1.34, P = .03; Table 2), but not in ɛ4 carriers (HR 1.08; 95% CI 0.88–1.33, P = .5; Table 2). This evidence concerns the gene APOE and Alzheimer disease.