APOE and dementia: In sensitivity analyses, APOE ɛ4 (HR 1.68; 95% CI 1.41–2.02, P = 1 × 10–8) and ɛ2 carriership (HR 0.76; 95% CI 0.59–0.97, P = .03) remained associated with incident dementia, after excluding APOE ɛ4/ɛ2 heterozygotes (n = 2015).