In conclusion, we demonstrate YXJD alleviates IMQ-induced psoriasis-like pathological changes in microvessels by inhibiting the expression of Survivin in endothelial cells via Survivin/PI3K/Akt pathway, which are related to apoptosis, autophagy, and angiogenesis of microvessels in psoriasis. This evidence concerns the gene BIRC5 and psoriasis.