Insulin-like growth factor 2 mRNA-binding protein 2/IGF-II mRNA-binding protein 2- (IGF2BP2/IMP2-) deficient mice have a higher level of the uncoupling protein 1 (UCP1) polypeptide in brown fat, contributing to the higher energy expenditure and resistance to diet-induced obesity [20]. This evidence concerns the gene UCP1 and obesity due to melanocortin 4 receptor deficiency.