Condotta et al. observed an increase in the expression of coinhibitory molecules, such as PD-1, LAG-3, and 2B4, and a decrease in the release of effector cytokines such as IFN-γ, TNF-α, and IL-2, suggesting that CD8+ T cells are exhausted in mice and patients with sepsis [160-162]. Here, CD8A is linked to Sepsis.