Moreover, DOX-induced mortality is reduced in receptor interacting serine/threonine kinase 3 knockout (Ripk3-/-) mice compared with wild-type littermates, while ferrostatin-1 treatment further extends the survival of DOX-induced cardiomyopathy compared with the vehicle-treated group in Ripk3-/- mice [26]. This evidence concerns the gene RIPK3 and cardiomyopathy.