The circulating memory compartment of Tfh, which is defined as CXCR5+CD4+ T cells, is profoundly skewed towards Tfh2 and Tfh17, as opposed to Tfh1 cells, in juvenile DM patients, and such altered overall Tfh cell differentiation has been linked to disease activity and the frequency of blood plasmablasts [83]. The gene discussed is CD4; the disease is dermatomyositis.