We found that the percentage of CNPase expressing area in the peri-infarct cortex was significantly reduced only in the Rccr5Dwt mice when compared with RwtDwt mice (p<0.01, Fig. 7A-D and J), suggesting that brain-derived CCR5 is required for post-brain ischemia myelination in the axons of the peri-infarct cortex. This evidence concerns the gene CCR5 and brain ischemia.