We have reported that healthy elderly subjects express high levels of proinflammatory soluble biomarkers, such as high sensitive C reactive protein, IL-8, IL-6 and TNF-α, similarly to the pattern observed once the “cytokine storm” emerges in COVID-19 severe disease, and a greater percentage of monocytes expressing proinflammatory and anti-inflammatory cytokines [16-17] compared with young subjects. The gene discussed is IL6; the disease is COVID-19.