As identified in the multivariate analyses, only high Fib level remained independently and positively related to the presence of high-risk PCa after adjusting for confounding factors including PSA, grade, and stage (T3 vs. T1, OR = 3.664, 95% CI: 1.719-7.808, p = 0.001). The gene discussed is FBL; the disease is posterior cortical atrophy.